Sunday, April 28, 2013

CA-BUSINESS Summary

TSX slides as mining, energy issues stumble

TORONTO (Reuters) - Canada's main stock market finished lower on Friday as natural resource stocks slumped and market sentiment soured following U.S. economic growth data that fell short of expectations. U.S. gross domestic product expanded at a 2.5 percent rate, an increase from the fourth quarter's dismal 0.4 percent pace but shy of the 3 percent growth analysts were hoping for. The weaker-than-expected data in Canada's biggest trading partner weighed on Canadian stocks.

Ethiopian Airlines first to fly 787 Dreamliner since grounding

ADDIS ABABA (Reuters) - Ethiopian Airlines on Saturday became the world's first carrier to resume flights with Boeing Co's 787 Dreamliner passenger jets, a Reuters witness said, three months after they were grounded over battery meltdowns. U.S. regulators approved a new battery design last week, clearing the way for installation and a resumption of Dreamliner flights by international carriers.

Italy court rejects seizure of Nomura assets in Monte Paschi probe: sources

SIENA, Italy (Reuters) - An Italian judge has rejected an order to seize around 1.8 billion euros ($2.3 billion) of assets from Nomura as part of a probe into suspected fraud involving troubled lender Monte dei Paschi di Siena , a judicial and a legal source said on Saturday. Prosecutors in Siena are investigating risky derivatives trades that have endangered the survival of Monte Paschi, the world's oldest bank.

Vodafone investors want bigger bid or full takeover by Verizon

LONDON (Reuters) - Six major Vodafone investors said $100 billion was not enough for the British company's stake in its U.S. joint venture with Verizon Communications , and urged the latter to come up with an offer of at least $120 billion. Their comments followed a Reuters report on Wednesday that Verizon had hired advisers to prepare a possible $100 billion bid to buy Vodafone's 45 percent stake in their Verizon Wireless joint venture, likely to be structured as a roughly 50:50 cash and stock bid.

Exclusive: Brazil's Vale says signs accord to quit Argentine Potash project

RIO DE JANEIRO (Reuters) - Global miner Vale SA signed an agreement with the Argentine government on Friday that will allow the Brazilian company to leave the $6 billion Rio Colorado potash mining project, a company spokeswoman told Reuters on Friday. The agreement could put an end to months of uncertainty for Vale , which suspended work on the fertilizer project in December and announced its intention to pull out in March.

Boeing ready to build seven Dreamliners a month by mid-year

TOKYO (Reuters) - Boeing Co said on Saturday it is ready to build seven 787 Dreamliners a month from mid-year and is still on course for 10 per month by the end of the year. On Friday, Japanese authorities gave Japan Airlines and All Nippon Airways the green light to fly the grounded Dreamliner following U.S. approval.

Renault hopes to have approval for Chinese plant by summer: CEO

PARIS (Reuters) - Renault-Nissan hopes to receive final approval from Beijing by the summer to build its first Renault plant in China, Chief Executive Carlos Ghosn said on Saturday. Ghosn had said last month he expected final government approval for the plant by the end of the year.

TransCanada sees Keystone XL delayed till second-half 2015

CALGARY, Alberta (Reuters) - TransCanada Corp , Canada's No. 2 pipeline company, said on Friday the long wait for U.S. government approval of its controversial Keystone XL project will further delay completion of the pipeline and push its cost above the company's $5.3 billion estimate. TransCanada, which reported a 27 percent rise in first-quarter profit on Friday, is waiting for the Obama administration to issue a presidential permit for construction of the line, which is designed to carry 830,000 barrels a day of Canadian and U.S. crude oil to refineries on the Gulf of Mexico coast.

U.S. sues Novartis over kickbacks

NEW YORK (Reuters) - The U.S. government on Friday announced its second civil fraud lawsuit against Novartis AG in four days, accusing a unit of the Swiss drugmaker of paying multimillion-dollar kickbacks to doctors in exchange for prescribing its drugs. Authorities said the Basel-based company for a decade lavished healthy speaking fees and "opulent" meals, including a nearly $10,000 dinner for three at the Japanese restaurant, Nobu, to induce doctors to prescribe its drugs.

Volkswagen committed to European plants: CEO

VIENNA (Reuters) - German carmaker Volkswagen will keep its plants in Europe despite weak markets in the region that will require flexible manufacturing and could entail cuts to temporary staff, Chief Executive Martin Winterkorn said. Winterkorn had told shareholders in Europe's top carmaker on Thursday to brace for a tough year given faltering European consumer demand that is punishing the sector.

Source: http://news.yahoo.com/ca-business-summary-000259603.html

st louis news correspondents dinner i am legend san antonio spurs greta van susteren tony parker the five year engagement

Friday, April 26, 2013

Disrupt Alum Zumper Launches An iPhone App To Help Real Estate Professionals Create Apartment Listings On The Fly

zumper-logoLast fall, Disrupt Battlefield finalist Zumper promised to make finding an apartment in San Francisco and New York City not quite so painful. With a map-based interface and easy-to-use filters, the startup sought to differentiate itself from the status quo by providing a better way to search for, and find, available apartments.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/tArXSlTkJmk/

mickelson how to tie a tie sweet potato recipes the sound of music celebration church new york auto show 2012 tulsa

Slow Insurance Approvals Strand Mental Health Patients in ER ...

By Rick Nauert PhD Senior News Editor
Reviewed by John M. Grohol, Psy.D. on April 25, 2013

Slow Insurance Approvals Strand Mental Health Patients in ER A significant problem regarding health care access involves obtaining hospital admission for those experiencing a mental health crisis.

The backlog in obtaining insurance approval for admission to a hospital bed is problematic for the patient in crisis, other emergency room patients and physicians.

A research letter to be published in the May issue of the journal Annals of Emergency Medicine argues that pre-authorization process is akin to health care ?rationing by hassle factor.?

?An emergency department is just about the worst place for a psychiatric patient to wait for an inpatient bed, and yet that is exactly what the pre-authorization process forces on millions of these vulnerable people,? said senior author J. Wesley Boyd, M.D., Ph.D.

?The thousands upon thousands of hours emergency physicians spend obtaining prior authorization for admission to the hospital are hours we are not spending on direct patient care. Only Medicare does not require prior authorization for us to admit psychiatric patients to the hospital; maybe they are onto something.?

In the study, researchers recorded data on 53 patients ? most were in the emergency department because they were having suicidal thoughts.

Half of the authorization requests took under 20 minutes to be approved, but 10 percent of the patients? authorizations took an hour or more. Only one of the 53 patients? insurance carriers denied pre-authorization. There are approximately 2.5 million psychiatric admissions to hospitals every year in the U.S.

?Psychiatric care is really the poor stepchild in the world of insurance coverage,? said lead author Amy Funkenstein, M.D., of Brown University in Providence, R.I..

?Insurance carriers reimburse poorly and as a consequence, hospitals often have inadequate resources for patients who urgently need this care. The situation is so dire that ERs are now being designed and configured to house psychiatric patients awaiting placement as inpatients. These patients deserve better.?

Source: American College of Emergency Physicians

Man waiting in the Emergency Room photo by shutterstock.

APA Reference
Nauert PhD, R. (2013). Slow Insurance Approvals Strand Mental Health Patients in ER. Psych Central. Retrieved on April 25, 2013, from http://psychcentral.com/news/2013/04/25/slow-insurance-approvals-strand-mental-health-patients-in-er/54083.html

?

Source: http://psychcentral.com/news/2013/04/25/slow-insurance-approvals-strand-mental-health-patients-in-er/54083.html

lotto winner jerry lee lewis winning lotto numbers lottery tickets mega lottery sag aftra mega mill

New grass hybrid could help reduce the likelihood of flooding

Apr. 25, 2013 ? A collaboration of plant and soil scientists from across the UK has shown a grass hybrid species could help reduce the impact of flooding.

The BBSRC-funded scientists, from Rothamsted Research, the James Hutton Institute, Institute of Biological, Environmental and Rural Sciences (IBERS) at Aberystwyth University, Lancaster University and the University of Nottingham, used a hybridised species of grass called perennial ryegrass (Lolium perenne) with a closely related species called meadow fescue (Festuca pratensis).

They hoped to integrate the rapid establishment and growth rate of the ryegrass with the large, well developed root systems and efficient water capture of the meadow fescue.

Over two years of field experiments in the south west the team demonstrated that the hybrid, named Festulolium, reduced water runoff from agricultural grassland by up to 51 per cent compared to a leading UK nationally-recommended perennial ryegrass cultivar and by 43 per cent compared to meadow fescue.

It is thought the reduced runoff is achieved because Festulolium's intense initial root growth and subsequent rapid turn-over, especially at depth, allows more water to be retained within the soil.

The hybrid grass also provides high quality forage with resilience to weather extremes, making the grass doubly useful to farmers.

Dr. Kit Macleod, catchment scientist at the James Hutton Institute and one of the authors of the paper, said: "Hybrid grasses of this type show potential for reducing the likelihood of flood generation, whilst providing pasture for food production under conditions of changing climate.

"In areas with similar climate and soils, then there is potential for reducing the likelihood of flood generation based on increased soil water storage within a river's catchment."

Professor Douglas Kell, Chief Executive of BBSRC, said: "We usually think of improving food crops solely in terms of traits such as the yield and quality of the food itself, and apart from root crops such as potatoes and carrots these are easily visible, above-ground traits. However, there is increasing recognition that the health and utility of plants can be greatly enhanced by improving below-ground traits such as root growth.

"This is a superb example of that reasoning, and a hugely important advance resulting from decades of fundamental BBSRC-supported work on the hybridisation of Lolium and Festuca (Fescue) species. I am sure that we shall see a continuing resurgence of interest in root biology, which findings such as this are sure to promote. The enormous savings that will be possible by mitigating flooding through planting grasses such as these dwarf any possible cost of producing them."

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by Biotechnology and Biological Sciences Research Council.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Christopher (Kit) J. A. Macleod, Mike W. Humphreys, W. Richard Whalley, Lesley Turner, Andrew Binley, Chris W. Watts, Leif Sk?t, Adrian Joynes, Sarah Hawkins, Ian P. King, Sally O'Donovan, Phil M. Haygarth. A novel grass hybrid to reduce flood generation in temperate regions. Scientific Reports, 2013; 3 DOI: 10.1038/srep01683

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/dM2PU6pN6mQ/130425103314.htm

jason wu for target collection nick diaz vs carlos condit the patriot hall of fame occupy dc ufc 143 fight card my fair lady

New advances in the management of patients with cirrhosis

Apr. 25, 2013 ? New data from clinical studies presented for the first time at the International Liver Congress? 2013 provide new rationale for an old and established treatment option for portal hypertension. Additionally, spleen stiffness predicts the occurrence of clinical complications, which is of paramount importance in clinical practice.

In patients with cirrhosis, increasing blood pressure in the abdominal circulatory system (known as portal hypertension) leads to potentially lethal complications which might be prevented with simple medical treatment. Patients with cirrhosis and portal hypertension have increased gastrointestinal permeability which allows the movement of bacteria or bacterial components through the lining of the gut into the blood stream in a process known as bacterial translocation. Bacterial components such as lipopolysaccharide can be involved in the genesis of complications of cirrhosis.

The first study evaluated the effects of a non-selective beta-blocker (NSBB) on gastrointestinal permeability and bacterial translocation in patients with cirrhosis with high levels of portal hypertension.1 Patients with severe portal hypertension (HVPG* ?20mmHg) had increased markers of gastrointestinal permeability and bacterial translocation compared to patients with lower levels of portal hypertension (HVPG<20mmHg). Treatment with NSBB significantly reduced HVPG, improved gastrointestinal permeability and decreased bacterial translocation (LPS-binding protein (LBP) -16% p=0.018; IL-6 -41% p< 0.0001) levels.

Patients who were found to have the highest levels of gastrointestinal permeability were also found to be at most risk of bleeding from esophageal varices; a complication of cirrhosis which carries a high risk of mortality.

These findings provide a new rationale for the use of non-selective beta-blockers in patients with cirrhosis. EASL's Treasurer Prof. Mauro Bernardi commented on the data: "The movement of bacteria from the gut and into the bloodstream is extremely serious and potentially fatal in patients with cirrhosis often leading to complications or death. Beta-blockers have been successfully used in a number of conditions and as a standard treatment to control blood pressure in other disease areas. In cirrhosis, they have been used for decades for primary and secondary prophylaxis of bleeding from esophageal varices. The results of this study show that besides improving portal hypertension, as it was thought up to now, their beneficial effects are also due to their ability to reduce bacterial translocation which may widen the indications for the use of these drugs in this setting."

In the diagnostic landscape, promising data to support the validity of non-invasive techniques were also presented at the congress. HVPG, an invasive measurement technique currently considered as the best predictor to identify progression to severe scarring of the liver and disrupted essential body functions (clinical decompensation), was compared to techniques such as the evaluation of spleen stiffness (SS) combined with the MELD** score.2 ?

The study showed that in compensated (early) patients with cirrhosis both the SS (p<0.0001) and the MELD (p=0.016) score provided an accurate prediction of clinical decompensation, and their combination in a new score had a predicting power even superior to that of HVPG.

Prof. Mauro Bernardi added, "HVPG is an invasive technique, which can often be discomforting for patients, is only performed in specialised centres and needs experienced operators to be fully reliable. While further studies will be required, if non-invasive techniques continue to present accurate predictions, they would be welcomed in the overall management of compensated patients with cirrhosis."

Notes

*HVPG or hepatic venous pressure gradient is the most widely used parameter for assessing portal hypertension

**MELD is a scoring system for assessing the severity of chronic liver disease

Compensated cirrhosis, where the body still functions fairly well despite scarring of the liver, is strongly associated with the development of portal hypertension.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by European Association for the Study of the Liver, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/d1-eaT2z-v8/130425091610.htm

man of steel gucci mane Chicago sinkhole Panda Express illuminati illuminati ricin

Thursday, April 25, 2013

Nintendo won't host a keynote at E3 2013, plans small but focused hands-on events instead

A lot of folks have been wondering just how Nintendo's keynote was going to outshine the launch of two competitor consoles at this year's E3. Turns out, it won't. During Nintendo's Japanese financial results briefing, company President Satoru Iwata revealed the company wouldn't be hosting a Keynote at E3 this year. "We decided not to host a large-scale presentation targeted at everyone in the international audience where we announce new information as we did in the past," Iwata explained. "Instead, at the E3 show this year, we are planning to host a few smaller events that are specifically focused on our software lineup for the US market." Nintendo will be hosting two events, actually -- one for distributors and another for the media. The company president says he won't personally be speaking at either event.

In lieu of the traditional keynote livestream, Nintendo will be releasing Nintendo Direct streams to deliver region specific news to Japanese and overseas fans. It's a bold, and perhaps dangerous move for the Japanese gaming giant. While bowing out of the keynote avoids the yearly squabble over who "won" E3 in the eyes of critics, it also forfeits the opportunities a large presentation provides, namely promotion. Excitable fans may have to wait until Nintendo Spaceworld to get their hype-fix.

Filed under:

Comments

Via: NeoGaf

Source: Nintendo

Source: http://www.engadget.com/2013/04/24/nintendo-wont-host-a-keynote-at-e3-2013-plans-small-but-focuse/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

aubrey plaza boston marathon turbotax nascar Catching Fire trailer Marfa Texas leonhard euler

Gut bacteria byproduct predicts heart attack and stroke

Apr. 24, 2013 ? A microbial byproduct of intestinal bacteria contributes to heart disease and serves as an accurate screening tool for predicting future risks of heart attack, stroke and death in persons not otherwise identified by traditional risk factors and blood tests, according to Cleveland Clinic research published today in The New England Journal of Medicine.

The research team was led by Stanley Hazen, M.D., Ph.D., Vice Chair of Translational Research, Chair of the Department of Cellular and Molecular Medicine for the Lerner Research Institute and section head of Preventive Cardiology & Rehabilitation in the Miller Family Heart and Vascular Institute at Cleveland Clinic, and W.H. Wilson Tang, M.D., Department of Cardiovascular Medicine in the Miller Family Heart and Vascular Institute and Lerner Research Institute.

The current study is an extension of Dr. Hazen's previous work, in which he found that a chemical byproduct called trimethylamine N-oxide (TMAO) is produced when intestinal bacteria digest the nutrient phosphatidylcholine, commonly known as lecithin. The prior research showed that TMAO levels in the blood were associated with heart disease. Dr. Hazen and colleagues have now confirmed that gut flora are essential in forming TMAO in humans and demonstrated a relationship between TMAO levels and future cardiac events like heart attack, stroke, and death -- even in those with no prior evidence of cardiac disease risk.

To demonstrate the role of gut flora in forming TMAO, human subjects were asked to eat two hard-boiled eggs (a common dietary source of lecithin) and a capsule of labeled lecithin (as a tracer). After ingestion, TMAO levels in the blood increased. However, when these same subjects were given a brief course of broad-spectrum antibiotics to suppress their gut flora, their TMAO levels were suppressed, and no additional TMAO was formed, even after ingesting lecithin. These results demonstrated that the intestinal bacteria are essential for the formation of TMAO.

In the second phase of the study, the researchers measured TMAO levels in a large, independent, clinical cohort -- consisting of more than 4,000 adults undergoing cardiac evaluation at Cleveland Clinic -- over a three-year follow-up period. They found that higher TMAO blood levels were associated with higher future risks of death and nonfatal heart attack or stroke over the ensuing three-year period, independent of other risk factors and blood test results. These results complement those of another recent study of Dr. Hazen's linking gut flora metabolism of a structurally similar nutrient found in animal products, carnitine, to TMAO production and heart attack risk.

"Heart disease remains the No. 1 killer, and while we know how to reduce cholesterol, treat blood pressure, and reduce cardiac risks through diet and other interventions, a substantial residual risk still remains," Dr. Hazen said. "We need to find new pathways to attack heart disease, and these findings strongly suggest that further research into the involvement of gut microbiome in the development of cardiovascular disease could lead to new avenues of prevention and treatment of heart disease."

Dr. Hazen further suggested, "These studies show that measuring blood levels of TMAO could serve as a powerful tool for predicting future cardiovascular risk, even for those without known risk factors. More studies are needed to confirm that TMAO testing, like cholesterol, triglyceride or glucose levels, might help guide physicians in providing individualized nutritional recommendations for preventing cardiovascular disease. Our goal is not to suggest dietary restrictions of entire food groups. Eggs, meat and other animal products are an integral part of most individuals' diets. Our work shows, however, that when digesting these foods, gut flora can generate a chemical mediator, TMAO, that may contribute to cardiovascular disease."

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by Cleveland Clinic, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. W.H. Wilson Tang, Zeneng Wang, Bruce S. Levison, Robert A. Koeth, Earl B. Britt, Xiaoming Fu, Yuping Wu, Stanley L. Hazen. Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk. New England Journal of Medicine, 2013; 368 (17): 1575 DOI: 10.1056/NEJMoa1109400

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/D14BpEQC7uQ/130424185211.htm

brandon jacobs brandon jacobs brian dawkins emma roberts north korea news north korea news giuliana and bill

The Complicated Chinese Family Tree: A Video Guide | MetaFilter

?

The Great Wall: worth some clicks. Nice kids, good presentations.
posted by mule98J at 10:35 AM on April 23 Oh wow this is awesome, and it looks like they sell posters too.

Funny aside, one of my friends has something like 9 brothers (and no sisters). In Chinese, you would normally refer to them as "oldest brother" or "second oldest brother" and so on. For some reason, they started doing this in English, and would say things like "Hey, how's two doing?"
posted by jasonhong at 10:37 AM on April 23 [1 favorite]

Pfft. Unrealistic--needs more canine little brothers/sisters in that family tree.

Trust me, they get lai sze and eat moon cakes, they're family.
posted by roquetuen at 2:49 PM on April 23

roquetuen, that's a cute comment :). Some of my Taiwanese friends call their pets "???" or "kids with fur", and do refer to them individually as "my daughter" or "my son".
posted by Alnedra at 11:53 PM on April 23

? Older Broadway stars get together to "preview" Downton A...??|??Shakuntala Devi, the Indian "h... Newer ?


Source: http://www.metafilter.com/127307/The-Complicated-Chinese-Family-Tree-A-Video-Guide

stock market stock market Obama Acceptance Speech 2012 dow jones Selena Gomez ariel winter Paige Butcher

Voice activated texting while driving no safer than using hands

A new study says voice texting is just as dangerous as using your hands (AP)Going hands free on your mobile device to send a text is no less dangerous than the traditional method, according to a new university study.

In fact, the risk is nearly identical, cutting reaction time for drivers in half.

?We believe it?s a useful step, and we?re eager to see what other studies may find,? said Christine Yager, who led the study for the Texas A&M Transportation Institute (TTI).

The study was conducted as part of National Distracted Driving Awareness Month.

A number of unsettling statistics have come out recently as part of the ongoing effort to help reduce the behavior called ?distracted driving.?

In March, a study found that adults are actually far more likely to text while driving than their teen counterparts. And another study released in early April found that daydreaming while driving results in thousands of fatal car accidents each year.

For its study, TTI tested 47 drivers on a closed course to measure their reaction times while using the two most popular voice-controlled texting applications, Siri and Vlingo.

The drivers went around the closed course three times: Once while not using their phone at all, once while texting with their hands and once while texting by voice. A stoplight appeared at random intervals while the drivers made their way around the course and the researchers compared how long it took the drivers to respond.

?Driver response times were significantly delayed no matter which texting method was used. In each case, drivers took about twice as long to react as they did when they weren?t texting,? an excerpt from the study reads.

Interestingly, drivers reported that they felt safer when texting via voice versus with their hands. However, the study found that texting by hand was actually slightly faster than texting by voice, along with posing the same general amount of risk.

The study did not specify why voice texting posed the same risk. But several factors could explain the results, including the fact that an individual must still look at their phone to read and send their text message, even if they are using a "hands free" device.

Source: http://news.yahoo.com/blogs/sideshow/voice-activated-texting-while-driving-no-safer-using-022223915.html

madonna guacamole recipe ufc 143 results kickoff time super bowl 2012 superbowl national anthem patriots vs giants super bowl superbowl halftime show

Kenya Reinsurance 2012 pretax profit jumps 45 pct

By Steve Slater LONDON (Reuters) - British bank Barclays' investment banking division beat expectations in the first quarter, outshining the wider group's earnings drop and sending its shares to a 6-week high. Overall profits at Britain's third-largest bank were down a quarter from a year ago, it said on Wednesday, due to the costs of new Chief Executive Antony Jenkins' plan to overhaul the lender after a series of scandals involving interest rate fixing, mis-selling of products and boardroom excess. ...

Source: http://news.yahoo.com/kenya-reinsurance-2012-pretax-profit-jumps-45-pct-075022347--sector.html

limp bizkit stations of the cross nike foamposite galaxy bill maher seabiscuit dingo nba all star weekend

Wednesday, April 24, 2013

Study: chicken, ground beef are riskiest meats

WASHINGTON (AP) ? An analysis of more than 33,000 cases of foodborne illness shows that ground beef and chicken have caused more hospitalizations than other meats.

The report by the Center for Science in Public Interest says chicken nuggets, ham and sausage pose the lowest risk of foodborne illness.

The group used government data on 1,700 incidents over 12 years to analyze outbreaks of salmonella, E. coli, listeria and other pathogens that were definitively linked to a certain meat.

To calculate which meats were riskiest, CSPI ranked the foods in which contamination was most likely to cause hospitalizations. Some meats may have had more illnesses but were less likely to cause severe illness.

Source: http://news.yahoo.com/study-chicken-ground-beef-riskiest-meats-153533823.html

bonnaroo 2012 lineup twisted metal sea lion si swimsuit 2012 westminster dog show abe lincoln vampire hunter xi jinping

Monday, April 22, 2013

Shipments of low-cost smart phones poised to dramatically increase

Optimus L5

Sub-$250 devices could represent as much as 46-percent of smart phones sold by 2018

As much as the latest high-end devices steal the news cycle (especially at a time like this), a large number of the phones sold around the world are still decidedly mid- and low-end. If analysis by ABI Research is to be believed, shipments of these low-end devices are going to increase at a much faster pace than the market as a whole. In 2018, 788 million low-end smart phones are expected to be shipped, compared to mid- and high-end devices combined at 925 million.

Depending on the market, the reasons for this may be slightly different, however. For emerging markets that are much more price-sensitive, low-end devices may be the only option those consumers have to get their hands on something with internet access. As carriers in those areas look to maximize profits from data traffic, they will push to have very inexpensive smart phones available for them.

In less price-sensitive (or heavily subsidized) markets like Western Europe and the U.S., there are still millions upon millions of people waiting to make that move from their feature phone onwards to a smart phone. Factoring the jump to a more expensive monthly rate including data, those consumers may need a stepping stone in the way of a more affordable (think $0 on-contract) option. These inexpensive phones also have the added bonus of carrying a smaller subsidy for the carriers to manage. Remember that while we like to focus on the highest of high-end devices, there's a whole market out there for phones that are a little more pedestrian.

Source: ABIresearch (BusinessWire)

    


Source: http://feedproxy.google.com/~r/androidcentral/~3/qWHE-yWmxok/story01.htm

christine christine double fine adventure turbo tax katharine mcphee cold mountain valentines day ideas

Commonly used drug can limit radiation damage to lungs and heart for cancer patients

Apr. 21, 2013 ? Unavoidable damage caused to the heart and lungs by radiotherapy treatment of tumours in the chest region can be limited by the administration of an ACE inhibitor, a drug commonly used in the treatment of cardiovascular disease, a group of Dutch researchers have found. [1]

Common cancers such as breast, esophagus, lung, and Hodgkin's lymphoma are frequently treated with radiotherapy, but the radiation dose that can be given safely is limited by the sensitivity of the health lung tissue which is also irradiated.

The lung is a particularly complex and sensitive organ and strategies for protecting it from radiotherapy damage, apart from limiting the dose given and, therefore, the efficacy of the treatment, are few. Presenting the research to the 2nd Forum of the European Society for Radiotherapy and Oncology (ESTRO) today (Sunday), Dr Sonja Van der Veen, MSc, from the University Medical Centre, Groningen, The Netherlands, said that she had set out with colleagues to see whether the use of an ACE inhibitor could protect against early radiation-induced lung toxicity (RILT). Previous studies had shown that damage to blood vessels can play an important role in the development of RILT [2], so the researchers irradiated the lungs, heart, or heart and lungs of rats and administered the ACE inhibiter captopril immediately after treatment. The rats' lung functions were then measured at two-weekly intervals.

"After eight weeks, when early lung toxicity is usually at its height, we found that captopril improved the rats' heart and lung functions, but we were surprised to find that this only occurred when the heart was included in the irradiation field," said Dr Van der Veen. "This was not due to protection of the lung blood vessels, which were equally damaged with or without captopril. So we investigated further and found that the captopril treatment improved the heart's function and decreased the level of fibrosis in the heart soon after irradiation. So these new findings show that ACE inhibition decreases RILT by reducing direct acute heart damage."

Irradiating the heart leads to the development of fibrosis, which stiffens it, and this in turn leads to problems in the relaxation of the left ventricle. Due to this, blood flow from the lungs into the heart is hindered, and this can cause pulmonary damage. However, after treatment with captopril, the researchers observed an improvement in ventricular relaxation in the irradiated hearts.

Dr Van der Veen and her colleagues are now collaborating with a research group from the Mayo Clinic, Rochester, Minnesota (USA), in order to design a randomised clinical trial where patients who are treated with radiation to the thoracic area including the heart will be treated with either an ACE inhibitor or a placebo after irradiation.

Much progress has been made in radiation treatment over recent years, but in breast cancer, for example, most women still receive high doses to the heart, and this is known to increase the risk of heart disease. A recent study [3] has shown that for each Gray (Gy) [4] of radiation, there is a 7.4% increase in the occurrence of a subsequent major coronary event.

"Given that most women will receive a dose of between 1 and 5 Gray, and that the dangers are even greater for women with existing cardiac risk factors or coronary disease, this is still a big problem," said Dr Van der Veen.

Rats were chosen for the study because, unlike mice, they are big enough for researchers to be able to irradiate different part of the lungs and heart. The researchers believe that the way in which ACE inhibition works in both animals and humans is similar.

"We are confident that our clinical trial will see the same protective effect in humans as that which we have seen in rats," said Dr Van der Veen. "We will also now begin to study the late effects of ACE inhibition on RILT to see whether it affords similar protection. We believe that our results suggest a promising strategy for shielding patients from radiation damage and improving their quality of life, while at the same time allowing them to receive a high enough dose to ensure the effective treatment of their cancer."

President of ESTRO, Professor Vincenzo Valentini, a radiation oncologist at the Policlinico Universitario A. Gemelli, Rome, Italy, said: "This study underlines the importance of translational research. The understanding of anti-cancer mechanisms, as well as of protective opportunities discovered in the experimental environment, is of upmost importance in the era of personalised medicine. This research provides further evidence of the importance of testing experimental theories in the clinical environment to the ultimate benefit of patients."

[1] ACE (angiotensin-converting enzyme) Inhibitors are a class of drugs usually used for treating high blood pressure and heart failure.

[2] Ghobadi G, Bartelds B, van der Veen SJ, Dickinson MG, Brandenburg S, Berger RM, et al. Lung irradiation induces pulmonary vascular remodelling resembling pulmonary arterial hypertension. Thorax 2012 Apr;67(4):334-341

[3] Darby SC, Ewertz M, McGale P, Bennet AM, Blom-Goldman U, Bronnum D, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med 2013 Mar 14;368(11):987-998.

[4] One Gray is the absorption of one joule of energy, in the form of ionising radiation, per kilogram of matter.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by ESTRO, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/AN_Sbo3phaI/130421074513.htm

spice girls justin theroux Bumbo recall USA Basketball taio cruz taio cruz Winter Olympics 2014

Sunday, April 21, 2013

Inhon Carbon Tablet unfolds for a CPU boost, wields a Surface-style keyboard

Inhon Carbon Tablet unfolds for overclocking, carries a Surfacestyle touch keyboard

Believe it or not, Inhon has a wilder concept up its sleeve than the extra-light Blade 13 Carbon laptop. Its equally new Carbon Tablet at first looks like it could pass for an IdeaPad Yoga, but the non-display half has little to do with input this time around -- besides USB 3.0 and Mini DisplayPort jacks, it's mostly about giving some breathing room to the Core i3, i5 or i7 inside. Keep the Windows 8 PC closed and it runs in a slower but quieter mode for handheld use; unfold it for some serious desk work, however, and a cooling fan inside ramps up to run the processor at TurboBoost speeds. Anyone who wants more traditional interaction has to attach an optional, Touch Cover-like keyboard and trackpad combo. We don't entirely grasp the logic when a convertible laptop might have done the trick, although estimated prices between NT $29,999 and NT $39,999 ($1,007 to $1,343 US) for the eventual launch in Taiwan will make it at least somewhat feasible to try Inhon's latest design experiment.

Filed under:

Comments

Source: Engadget Chinese (translated)

Source: http://www.engadget.com/2013/04/20/inhon-carbon-tablet-unfolds-for-a-cpu-boost/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

kurt busch nba dunk contest 2012 act of valor woody guthrie benson henderson 2012 dunk contest edgar vs henderson

Friday, April 19, 2013

"From the Front Lines" (talking-points-memo)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories Stories, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/300200836?client_source=feed&format=rss

watchmen hitch justin beiber lamar odom perfect game jon jones vs rashad evans results rashad evans

Farage Unleashed: "You Are Common Criminals" | Zero Hedge

"Years ago, Mrs Thatcher recognized the truth behind the European Project," UKIP's Nigel Farage reminds his European Parliament 'colleagues', "she saw that it was about taking away democracy from nation states and handing that power to largely unaccountable people." In one of his most wonderfully vitriolic remonstrations, the fiery Farage blasts Europe's leadership, "this European Union is the new communism." Slamming Olli Rehn and his Troika cohorts for "resorting to the level of common criminals and stealing people's money", Farage warns, rather chillingly, that, "it is power without limits. It is creating a tide of human misery and the sooner it is swept away the better." Simply put, he concludes, the European Parliament is living out a federal fantasy which is no longer sustainable.

?

Full Transcript:

Years ago, Mrs Thatcher recognised the truth behind the European Project. She saw that it was about taking away democracy from nation states and handing that power to largely unaccountable people.

?

Knowing as she did that the euro would not work she saw that this was a very dangerous design. Now we in UKIP take that same view and I tried over the years in this parliament to predict what the next moves would be as the euro disaster unfolded.

?

But not even me, in my most pessimistic of speeches would have imagined, Mr Rehn, that you and others in the Troika would resort to the level of common criminals and steal money from peoples' bank accounts in order to keep propped up this total failure that is the euro.

?

You even tried to take money away from the small investors in direct breach of the promise you made back in 2008.

?

Well the precedent has been set, and if we look at countries like Spain where business bankruptcies are up 45% year on year, we can see what your plan is to deal with the other bailouts as they come.

?

I must say, the message this sends out to investors is very loud and clear: Get your money out of the Eurozone before they come for you.

?

What you have done in Cyprus is you actually sounded the death knell of the euro. Nobody in the international community will have confidence in leaving their money there.

?

And how ironic to see the Russian prime minister Dmitry Medvedev compare your actions and say, ' I can only compare it to some of the decisions taken by the Soviet authorities.'

?

And then we have a new German proposal that says that actually what we ought to do is confiscate some of the value of peoples' properties in the southern Mediterranean eurozone states.

?

This European Union is the new communism. It is power without limits. It is creating a tide of human misery and the sooner it is swept away the better.

?

But what of this place, what of the parliament? This parliament has the ability to hold the Commission to account.? I have put down a motion of censure debate on the table. I wonder whether any of you have the courage to recognise it and to support it. I very much doubt that.

?

And I am minded that there is a new Mrs Thatcher in Europe and he is called Frits Bolkenstein. And he has said of this parliament - remember he is a former Commissioner: 'It is not representative anymore for the Dutch or European citizen. The European Parliament is living out a federal fantasy which is no longer sustainable.'

?

How right he is.

Your rating: None Average: 4.9 (96 votes)

Source: http://www.zerohedge.com/news/2013-04-17/farage-unleashed-you-are-common-criminals

bay bridge band of brothers presidents george washington russell westbrook horsetail falls ice t

Thursday, April 18, 2013

Plasma device could revolutionize energy generation and storage

Apr. 16, 2013 ? University of Missouri engineer Randy Curry and his team have developed a method of creating and controlling plasma that could revolutionize American energy generation and storage. Besides liquid, gas and solid, matter has a fourth state, known as plasma. Fire and lightning are familiar forms of plasma. Life on Earth depends on the energy emitted by plasma produced during fusion reactions within the sun.

Curry's device launches a ring of plasma as far as two feet. The plasma doesn't emit radiation, and it is completely safe for humans to be in the same room with it, although the plasma reaches a temperature hotter than the surface of the sun. The secret to Curry's success was developing a way to make the plasma form its own self-magnetic field, which holds it together while it travels through the air.

"Launching plasma in open air is the 'Holy Grail' in the field of physics," said Curry, professor of electrical and computer engineering in the University of Missouri's College of Engineering. "Creating plasma in a vacuum tube surrounded by powerful electromagnets is no big deal; dozens of labs can do that. Our innovation allows the plasma to hold itself together while it travels through regular air without any need for containment."

Curry warns that without federal funding of basic research, America will lose the race to develop new plasma energy technologies. The basic research program was originally funded by the Office of Naval Research, but continued research has been funded by MU.

The plasma device at MU could be enlarged to handle much larger amounts of energy, according to Curry. With sufficient funding, they could develop a system within three to five years that would also be considerably smaller. He noted that they used old technologies to build the current prototype of the plasma-generating machine. Using newer, miniaturized parts, he suggests they could shrink the device to the size of a bread box.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by University of Missouri-Columbia.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_technology/~3/vyoHt2fog8g/130416151931.htm

minnesota caucus knowshon moreno knowshon moreno sovereign citizen komen chrome for android hatchet

Tuesday, April 16, 2013

Shake This Curvaceous Spice Grinder For Perfectly Pulverized Seasonings

If you like to be as physically involved with your cooking as possible, swap your electric spice grinder for this beautiful alternative that puts a unique spin—or shake—on the traditional mortar and pestle. Inside the Paprikum is a polished metal ball bearing that can turn any dried spice into a powder in no time. More »
    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/U3fmvnSrS88/shake-this-curvaceous-spice-grinder-for-perfectly-pulverized-seasonings

megamillions winning numbers lotto winner jerry lee lewis winning lotto numbers lottery tickets mega lottery sag aftra

Israel at 65: Success still plagued by uncertainty

JERUSALEM (AP) ? In 65 years, Israel has surpassed the dreams of its founders, emerging as the Middle East's strongest military force, a global high-tech powerhouse and a prosperous homeland for the Jewish people.

Yet it remains a divided society, and its most intractable problem ? peace with its Arab neighbors ? has yet to be resolved.

On the eve of the 65th anniversary of its creation, the Jewish renaissance in the Holy Land remains a work in progress.

Dominating the short term is Iran's nuclear program, which Israel believes is aimed at developing an atomic weapon that could be used against the Jewish state, despite Iranian denials. Unrest along Israel's borders is equally worrisome.

Over the longer term, reaching peace with the Palestinians remains elusive, with the sides unable to agree even on how to restart negotiations. Palestinians consider creation of Israel a catastrophe that caused a stubborn refugee problem.

The 46-year occupation of Palestinian territories also ignites domestic and international tensions. Without a partition, Arabs could one day outnumber Jews, threatening Israel's democratic nature.

Israel began observing its annual Memorial Day on Sunday evening, honoring fallen soldiers and victims of militant attacks. At 8 p.m., air raid sirens sounded nationwide to mark a minute of silence. A two-minute siren was set for Monday morning.

At sundown Monday, the country abruptly shifts its mood to mark its 65th Independence Day with fireworks, military processions and picnics. The transformation from grief to joy is an annual ritual meant to show the link between the sacrifices and the accomplishments.

"Today there are also those who rise up against us and threaten to destroy us. They did not succeed in the past, and they will never succeed," Prime Minister Benjamin Netanyahu told a Memorial Day ceremony Sunday. Netanyahu's older brother, Yonatan, was killed in a military operation in 1976.

Israel declared independence on May 14, 1948. Israel marks the day according to the lunar Hebrew calendar. This year the Hebrew date comes out April 15-16 on the calendar used in the West.

Since Israel's creation, it has been in a constant state of conflict with its neighbors, most recently eight days of exchanges last November with Palestinian militants firing rockets from the Gaza Strip. It has signed peace treaties with just two Arab nations, Egypt and Jordan.

Yet the country is thriving in other ways. It has weathered the global financial crisis better than most, with unemployment below 7 percent and a growing economy. As a "startup nation," it has pioneered breakthroughs, including Wi-Fi technology, the computer firewall and instant messaging. In the past decade, Israeli scientists have won six Nobel prizes in chemistry and economics.

It has absorbed immigrants from more than 100 countries to host the world's largest Jewish population, evolving from a largely agrarian backwater to consistently rank high in measures of standard of living. Israel has given the world international supermodels, and its war history has inspired Oscar-nominated films and a TV series that was adapted into "Homeland," the award-winning American show.

"The state of Israel is truly a fantastic success story, perhaps among the greatest success stories of the 20th century," said Tom Segev, an Israeli author and historian. "There's an Israeli culture, a renewal of the Hebrew language. The most amazing thing is that we now have a third generation of Israelis for whom the country is a given. 'Israeliness' has become something that we take for granted."

On the other hand, Segev noted that the country is still grappling with the same basic issue that plagued it in 1948 ? its relations with the Palestinians.

Israel still does not have internationally recognized borders, and remains in control of about 2.5 million Arabs living in the West Bank and east Jerusalem. Israel captured the areas, along with the Gaza Strip, in the 1967 Mideast war, withdrawing from Gaza in 2005. The Palestinians claim all three territories for a future state.

"We haven't been able to solve this and we may not be able to solve it all," Segev said. "Most Israelis look at the Palestinian issue as a military problem and not a political problem. As long as it is quiet and there is no terror, we think everything is fine."

Israelis argue that the Palestinians have rejected generous peace offers, a claim the Palestinians reject, pointing to Israel's construction of Jewish settlements in the West Bank and east Jerusalem as a sign of bad faith.

Nahum Barnea, a veteran newspaper columnist, said that even if Israel can resolve its conflict with the Palestinians, its place in the heart of the Muslim world will never be certain.

"The occupation (of the West Bank) is an open wound. But even if the occupation were to miraculously end, the country's relations with the rest of the world would not suddenly be solved," he said. "Our struggle is not behind us. It is with us and ahead of us."

Israel has serious internal problems as well.

About 20 percent of its 8 million citizens are Arabs, who are often treated like second-class citizens and frequently identify with the Palestinians.

Nearly 10 percent of Israelis are ultra-Orthodox Jews, who have clashed with the general public over their dependence on welfare instead of work, refusal to serve in the military and attempts to impose their strict practices on broader society.

More than half of Israel's first grade students are now either Arab or ultra-Orthodox Jews, predicting a future demographic makeup that is less loyal to the state and less productive to its workforce.

Israel's transformation into a high-tech, knowledge-based economy has also fueled a growing gap between rich and poor, setting off protests in the summer of 2011 against the country's high cost of living.

Despite all their issues, Israelis are among the world's happiest people. Recent surveys by the OECD, Gallop and the United Nations' World Happiness Report all had Israel near the top.

Most Israelis appear to have developed an ability to block out the nation's problems and focus on life in a country that just a century ago was just a dream.

"Israelis feel that things are good with them, but not with the state," Segev said.

___

Follow Heller on Twitter (at)aronhellerap

Source: http://news.yahoo.com/israel-65-success-still-plagued-uncertainty-182619310.html

MBTA national signing day Solomon Islands Mary Leakey Side Effects weather nyc bob marley

Monday, April 15, 2013

Irritable Bowel Syndrome | Natural Holistic Health Blog

Are you having problems with your digestion? If it involves the lower half of the digestive tract it could be irritable bowel syndrome. Here are some facts to help you decide.

Irritable bowel syndrome, or IBS, is a condition involving the intestines. There are no clear-cut causes of the condition but it can lead to very painful situations for those affected.

In the intestinal tract, different triggers cause bowels to move differently than they did before. There are usually no visible signs such as inflammation, polyps or tumors that signal that irritable bowel is going on. Those who suffer from IBS often experience abdominal cramping, diarrhea, pain in the abdomen and constipation.

Those who have this condition also deal with bloating and gas. The symptoms may swing from diarrhea to constipation at different times. Doctors can help diagnose it from your description of your symptoms and a physical exam.

Who is at risk for irritable bowel syndrome? Those who have a family history won?t necessarily develop the condition but the odds are not in their favor. It usually occurs in women more than men and young people more so than older adults.

People with certain mental disorders (like depression and psychological trauma) are at risk. Also, those who have experienced abuse in their past, have a greater risk of developing irritable bowel syndrome than others. Fibromyalgia is also a risk factor because it affects the muscles throughout the body.

Once you develop irritable bowel syndrome, you will always have it. Managing the pain involves knowing your triggers and treating the symptoms. Your doctor may perform an endoscopic procedure to look at your intestine and see if something else is going on there that could be causing similar symptoms.

How can you treat the symptoms of IBS? First examine your lifestyle. While there is no direct correlation between food and irritable bowel syndrome, people often experience attacks after they eat. Learning food triggers is one step.

Stress can cause all types of reactions in the body. When it is unmanaged, it can cause gastrointestinal problems. Learning to handle situations in your life that are leading to stress, can reduce its part in the problem.

Exercise helps to bring the body back into optimal health. When the body is receiving proper nutrition and maintains a healthy weight, it is easier for the immune system to fight against illness. Regular physical activity may alleviate some of the symptoms of IBS.

Do you have gastrointestinal problems? See your doctor because you may be suffering from irritable bowel syndrome. While it affects the colon, your symptoms can be controlled through lifestyle changes and medication.

Your doctor may also prescribe medication if diet and exercise don?t make any significant change.

Free PDF Health Ebook...

Improve Your Self-Esteem in One Weekend

? ? Simply right click the ebook title above, and choose Save As to save to your desktop!? You can find more FREE Natural Health, Wellness and Pet Ebooks at Remedies4.com!


About Dee Braun

Dee is an Adv. Certified Aromatherapist, Reiki Master, Adv. Color/Crystal Therapist, Herbalist, Dr. of Reflexology and single mom who is dedicated to helping others any way she can. One way she chooses to help is by offering information on the benefits and uses of natural health and healing methods for the well-being of both people and pets. Dee also teaches Aromatherapy, Reflexology and Color/Crystal Therapy at the Alternative Healing Academy

Source: http://www.natural-holistic-health.com/irritable-bowel-syndrome/?utm_source=rss&utm_medium=rss&utm_campaign=irritable-bowel-syndrome

kansas jayhawks mega millions results lotto numbers susan powell megamillions winners university of louisville louisville ky

MyImgur Instantly Uploads Photos From Your Desktop to Imgur

MyImgur Instantly Uploads Photos From Your Desktop to Imgur Windows: Imgur is our favorite online image sharing service, and MyImgur is the fastest way to upload your files to the service and generate public links.

The execution is simple and seamless. Just drag an image onto the MyImgur window, and it will instantly upload to imgur. Buttons at the top of the window let you open the file in a browser or copy the URL to your clipboard, but you can set the app to do these by default if you prefer. Sign in with your imgur account, and you'll also be able to add images to your custom albums and monitor your upload limit.

On the surface, this is a very simple app, but dig a little deeper, and it's packed with advanced features. A built in screenshot tool lets you capture a portion of your screen and upload it instantly. If bandwidth is an issue, you can tell the application to scale your large photos automatically. You can even edit the file naming structure of your screenshots to keep them organized.

The interface certainly isn't as nice as FluffyApp, but it's hard to beat if you just want to share images quickly without setting up a CloudApp account.

MyImgur 3.1 (Free) | Via GHacks

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/jUxAGIPmO8w/myimgur-instantly-uploads-photos-to-imgur-from-your-desktop

aziz ansari aziz ansari katherine jenkins peyton manning broncos mexico city earthquake stand your ground law dancing with the stars season 14

Sunday, April 14, 2013

Breast cancer drug receives &#39;breakthrough therapy&#39; designation from ...

An experimental drug being investigated for the treatment of advanced breast cancer by researchers from the Revlon/UCLA Women's Cancer Research Program at UCLA's Jonsson Comprehensive Cancer Center this week received "breakthrough therapy" designation from the U.S. Food and Drug Administration.

?

In a clinical trial, patients with advanced breast cancer that was estrogen-receptor positive (ER+) and HER2-negative (HER2-), and who were given palbociclib (PD 0332991, Pfizer Inc.) in addition to the standard anti-estrogen treatment of letrozole had significantly higher progression-free survival ? the length of time a patient is on treatment without tumor growth ? than patients taking letrozole alone.

?

Enacted as part of the 2012 FDA Safety and Innovation Act, the breakthrough therapy designation was created by the agency to expedite the development and review of a potential new medicine if it is "intended, alone or in combination with one or more other drugs, to treat a serious of life-threatening disease or condition and preliminary clinical evidence indicates that the drug may demonstrate substantial improvement over existing therapies on one or more clinically significant endpoints."

?

Dr. Richard S. Finn, associate professor of medicine at the Jonsson Cancer Center, initially reported the phase 2 clinical data supporting the designation in December 2012 at the CTRC-AACR San Antonio Breast Cancer Symposium. The clinical study was built on laboratory work from the Translational Oncology Research Laboratory directed by Dr. Dennis Slamon, professor of medicine at UCLA and director of the Jonsson Cancer Center's Revlon/UCLA Women's Cancer Research Program.

?

In preclinical work, palbociclib was tested in a panel of human breast cancer cells growing in culture dishes and showed very encouraging activity, specifically against ER+ cancer cells. These preclinical observations were then moved into phase 1 clinical studies. Led by Finn and Slamon at UCLA, the studies were designed to determine the doses and safety of a combination with letrozole, a commonly used drug for ER+ breast cancer.

?

Once the phase 1 studies were completed, the phase 2 studies were performed in 165 patients with breast cancer with ER+ disease. The drug was designated as a breakthrough therapy by the FDA based on the preliminary analysis of the phase 2 data showing that the median progression-free survival of patients given the palbociclib-letrozole combination was 26.1 months, compared with 7.5 months for those given letrozole alone. Among patients with measurable disease, 45 percent receiving the combination had confirmed responses, compared with 31 percent for letrozole alone, and the clinical benefit rates (tumor shrinkage and/or stable disease for a minimum of six months) were 70 percent for those receiving the combination therapy, versus 44 percent for letrozole only.

?

"This drug combination demonstrated a dramatic and clinically meaningful effect on progression-free survival in women with ER+ breast cancer," Finn said. "These results confirm the preclinical work we began at the Translational Lab."


Finn and colleagues have initiated a randomized, multicenter, double-blind phase 3 study to evaluate palbociclib combined with letrozole, compared with letrozole alone, as a first-line treatment for post-menopausal patients with ER+, HER2-, locally advanced or metastatic breast cancer. The researchers will continue to work closely with Pfizer and the FDA to better understand the implications of the breakthrough therapy designation with the hope that further study will support potential regulatory submission.

?

Slamon said the phase 2 study results validate the Translational Laboratory's approach.

?

"By identifying the correct targets for treatment in the right patient population, we move forward with personalized oncology that we hope will greatly improve the outcomes for this group of breast cancer patients," he said. "These results are as exciting as the initial results we saw for trastuzumab (Herceptin) in HER2+ breast cancers but represent a new approach for a different and larger subset of breast cancers, namely those that are ER+."

?

Slamon said the researchers are working diligently to enroll the phase 3 validation study as quickly and safely as possible.

?

UCLA's Jonsson Comprehensive Cancer Center has more than 240 researchers and clinicians engaged in disease research, prevention, detection, control, treatment and education. One of the nation's largest comprehensive cancer centers, the Jonsson center is dedicated to promoting research and translating basic science into leading-edge clinical studies. In July 2012, the Jonsson Cancer Center was once again named among the nation's top 10 cancer centers by U.S. News & World Report, a ranking it has held for 12 of the past 13 years.

Source: http://newsroom.ucla.edu/portal/ucla/breast-cancer-drug-receives-breakthrough-245162.aspx

Kwame Kilpatrick New pope 2013 good morning america earthquake california earthquake california douglas adams brandon knight

A Lego Neck Strap Sets This Bricked Camera Apart From the Rest

Flickr user RGB900's Lego DSLR is far from the first bricked camera we've brought you. But damned if it isn't one of the most detailed. One of its most impressive features is a flexible neck strap, presumably made from tank tread pieces. And the inclusion of an external flash that appears to be connected via an actual Lego hotshoe is the icing on the cake. Bravo. More »
    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/sPhM4qbD3D0/a-lego-neck-strap-sets-this-bricked-camera-apart-from-the-rest

steven tyler tropic thunder carnie wilson missing reese witherspoon pregnant billy joel bent